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Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

Aditya Murthy, Yang Washington Shao, Swami R. Narala, Sam D. Molyneux, Juan Carlos Zúñiga-Pflücker, Rama Khokha

Journal:

Immunity

Année:

2012

Langue:

english

Fichier:

PDF, 2.89 MB

english, 2012

Differential expression of matrix metalloproteinases and their inhibitors in non-small cell lung cancer

Thomas, Pascal, Khokha, Rama, Shepherd, Frances A., Feld, Ronald, Tsao, Ming-Sound

Journal:

The Journal of Pathology

Année:

2000

Langue:

english

Fichier:

PDF, 208 KB

english, 2000

Increased collagen and aggrecan degradation with age in the joints of Timp3−/− mice

Solmaz Sahebjam, Rama Khokha, John S. Mort

Journal:

Arthritis & Rheumatism

Année:

2007

Langue:

english

Fichier:

PDF, 277 KB

english, 2007

Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration

Fazilat F. Mohammed, Caroline J. Pennington, Zamaneh Kassiri, Jeffrey S. Rubin, Paul D. Soloway, Ulrich Ruther, Dylan R. Edwards, Rama Khokha

Journal:

Hepatology

Année:

2005

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2005

Increased tumor necrosis factor α–converting enzyme activity induces insulin resistance and hepatosteatosis in mice

Loredana Fiorentino, Alessia Vivanti, Michele Cavalera, Valeria Marzano, Maurizio Ronci, Marta Fabrizi, Stefano Menini, Giuseppe Pugliese, Rossella Menghini, Rama Khokha, Renato Lauro, Andrea Urbani,

Journal:

Hepatology

Année:

2010

Langue:

english

Fichier:

PDF, 844 KB

english, 2010

Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis

Sefer Elezkurtaj, Charlotte Kopitz, Andrew H. Baker, Alejandra Perez-Cantó, Matthias J. E. Arlt, Rama Khokha, Bernd Gansbacher, Martina Anton, Karsten Brand, Achim Krüger

Journal:

The Journal of Gene Medicine

Année:

2004

Langue:

english

Fichier:

PDF, 272 KB

english, 2004

Up-regulation of TIMP-1 expression in B16-F10 melanoma cells suppresses their metastatic ability in chick embryo

Rama Khokha, Mitchell J. Zimmer, Sylvia M. Wilson, Ann F. Chambers

Journal:

Clinical and Experimental Metastasis

Année:

1992

Langue:

english

Fichier:

PDF, 551 KB

english, 1992

Steps in tumor metastasis: new concepts from intravital videomicroscopy

Ann F. Chambers, Ian C. MacDonald, Eric E. Schmidt, Sahadia Koop, Vincent L. Morris, Rama Khokha, Alan C. Groom

Journal:

Cancer and Metastasis Reviews

Année:

1995

Langue:

english

Fichier:

PDF, 4.52 MB

english, 1995

10.1038/73163

Dennis, James W., Granovsky, Maria, Fata, Jimmie, Pawling, Judy, Muller, William J., Khokha, Rama

Journal:

Nature Medicine

Année:

2000

Langue:

english

Fichier:

PDF, 876 KB

english, 2000

Progesterone induces adult mammary stem cell expansion

Joshi, Purna A., Jackson, Hartland W., Beristain, Alexander G., Di Grappa, Marco A., Mote, Patricia A., Clarke, Christine L., Stingl, John, Waterhouse, Paul D., Khokha, Rama

Journal:

Nature

Année:

2010

Langue:

english

Fichier:

PDF, 716 KB

english, 2010

Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line

Orr, F William, Rüther, Ulrich, Khokha, Rama, Krüger, Achim, Sanchez-Sweatman, Otto H, Martin, David C, Fata, Jimmie E, Ho, Andrew T

Journal:

Oncogene

Année:

1998

Langue:

english

Fichier:

PDF, 525 KB

english, 1998

Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma

Moorehead, Roger A, Sanchez, Otto H, Baldwin, R Mitchell, Khokha, Rama

Journal:

Oncogene

Année:

2003

Langue:

english

Fichier:

PDF, 291 KB

english, 2003

The bacterial lacZ gene: An important tool for metastasis research and evaluation if new cancer therapies

Achim Krüger, Volker Schirrmacher, Rama Khokha

Journal:

Cancer and Metastasis Reviews

Année:

1998

Fichier:

PDF, 986 KB

1998

Inhibition of VLA-4 and up-regulation of TIMP-1 expression in B16BL6 melanoma cells transfected with MHC class I genes

Fan Xu, Tim Carlos, Mengfeng Li, Otto Sanchez-Sweatman, Rama Khokha, Elieser Gorelik

Journal:

Clinical and Experimental Metastasis

Année:

1998

Langue:

english

Fichier:

PDF, 1.19 MB

english, 1998

Expression of bone sialoprotein and osteopontin in breast cancer bone metastases

Tharwat Ibrahim, Iona Leong, Otto Sanchez-Sweatman, Rama Khokha, Jaro Sodek, Howard C. Tenenbaum, Bernard Ganss, Sela Cheifetz

Journal:

Clinical and Experimental Metastasis

Année:

2000

Langue:

english

Fichier:

PDF, 227 KB

english, 2000

Temporal expression of tissue inhibitors of metalloproteinases in mouse reproductive tissues during gestation

Paul Waterhouse, David T. Denhardt, Dr. Rama Khokha

Journal:

Molecular Reproduction and Development

Année:

1993

Langue:

english

Fichier:

PDF, 837 KB

english, 1993

Increased proteinase expression during tumor progression of cell lines down-modulated for TIMP levels: a new transformation paradigm?

Rama Khokha, Paul Waterhouse, Peeyush Lala, Mitchell Zimmer, David T. Denhardt

Journal:

Journal of Cancer Research and Clinical Oncology

Année:

1991

Fichier:

PDF, 23 KB

1991

Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice

Alison Aiken, Rama Khokha

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2010

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2010

Thinking outside the cell: proteases regulate hepatocyte division

Fazilat F. Mohammed, Rama Khokha

Journal:

Trends in Cell Biology

Année:

2005

Langue:

english

Fichier:

PDF, 247 KB

english, 2005

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/− mice

Anthony Fyles, Geoffrey Wood, Ming Li, Armen S. Manoukian, Katrina Gowing, Rama Khokha, William Chapman, Ming-Sound Tsao

Journal:

Gynecologic Oncology

Année:

2008

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2008

Timp-1 Is Important for Epithelial Proliferation and Branching Morphogenesis during Mouse Mammary Development

Jimmie E. Fata, Kevin J. Leco, Roger A. Moorehead, David C. Martin, Rama Khokha

Journal:

Developmental Biology

Année:

1999

Langue:

english

Fichier:

PDF, 697 KB

english, 1999

Effects of the Disintegrin Eristostatin on Individual Steps of Hematogenous Metastasis

Vincent L. Morris, Eric E. Schmidt, Sahadia Koop, Ian C. MacDonald, Marsha Grattan, Rama Khokha, Mary A. McLane, Stefan Niewiarowski, Ann F. Chambers, Alan C. Groom

Journal:

Experimental Cell Research

Année:

1995

Fichier:

PDF, 675 KB

1995

Effects of levonorgestrel on enzymes responsible for synthesis of triacylglycerols in rat liver

Rama Khokha, Paul A. Walton, Fred Possmayer, Bernard Wolfe

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Année:

1987

Langue:

english

Fichier:

PDF, 528 KB

english, 1987

Clipping, shedding and RIPping keep immunity on cue

Gillian Murphy, Aditya Murthy, Rama Khokha

Journal:

Trends in Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 796 KB

english, 2008

A protective role for TIMP3 in acute lung injury

Sean E. Gill, Isham Huizar, Eli M. Bench, Negin Nazarian, Kevin J. Leco, Rama Khokha, Bill C. Parks

Journal:

Matrix Biology

Année:

2008

Langue:

english

Fichier:

PDF, 61 KB

english, 2008

Active allies: hormones, stem cells and the niche in adult mammopoiesis

Purna A. Joshi, Marco A. Di Grappa, Rama Khokha

Journal:

Trends in Endocrinology & Metabolism

Année:

2012

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2012

A null mutation for Tissue Inhibitor of Metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis

Sean E Gill, M.Cynthia Pape, Rama Khokha, Andrew J Watson, Kevin J Leco

Journal:

Developmental Biology

Année:

2003

Langue:

english

Fichier:

PDF, 796 KB

english, 2003

Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues

Kevin J. Leco, Suneel S. Apte, Gary T. Taniguchi, Susan P. Hawkes, Rama Khokha, Gilbert A. Schultz, Dylan R. Edwards

Journal:

FEBS Letters

Année:

1997

Langue:

english

Fichier:

PDF, 842 KB

english, 1997

The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development

Jimmie E Fata, Young-Yun Kong, Ji Li, Takehiko Sasaki, Junko Irie-Sasaki, Roger A Moorehead, Robin Elliott, Sheila Scully, Evelyn B Voura, David L Lacey, William J Boyle, Rama Khokha, Josef M Penninge

Journal:

Cell

Année:

2000

Langue:

english

Fichier:

PDF, 672 KB

english, 2000

Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis

Gavin Y. Oudit, Andrew M. Herzenberg, Zamaneh Kassiri, Denise Wong, Heather Reich, Rama Khokha, Michael A. Crackower, Peter H. Backx, Josef M. Penninger, James W. Scholey

Journal:

The American Journal of Pathology

Année:

2006

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2006

Tissue Inhibitor of Metalloproteinases 3 Regulates Resolution of Inflammation following Acute Lung Injury

Sean E. Gill, Isham Huizar, Eli M. Bench, Samuel W. Sussman, Ying Wang, Rama Khokha, William C. Parks

Journal:

The American Journal of Pathology

Année:

2010

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2010

Lack of Tissue Inhibitor of Metalloproteinases-3 Results in an Enhanced Inflammatory Response in Antigen-Induced Arthritis

Mandana Mahmoodi, Solmaz Sahebjam, David Smookler, Rama Khokha, John S. Mort

Journal:

The American Journal of Pathology

Année:

2005

Langue:

english

Fichier:

PDF, 1.90 MB

english, 2005

The mammary stem cell conundrum: is it unipotent or multipotent?

Purna A Joshi, Rama Khokha

Journal:

Breast Cancer Research

Année:

2012

Langue:

english

Fichier:

PDF, 91 KB

english, 2012

Hypotriglyceridemic effects of levonorgestrel in rats

Rama Khokha, Bernard M. Wolfe

Journal:

Atherosclerosis

Année:

1984

Langue:

english

Fichier:

PDF, 722 KB

english, 1984

Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/prolactin gene superfamily

Alison M. Connor, Paul Waterhouse, Rama Khokha, David T. Denhardt

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

1989

Langue:

english

Fichier:

PDF, 1.35 MB

english, 1989

Proteolytic factors in exosomes

Shimoda, Masayuki, Khokha, Rama

Journal:

PROTEOMICS

Année:

2013

Langue:

english

Fichier:

PDF, 316 KB

english, 2013

QUANTIFYING NANOPARTICLE TRANSPORT IN VIVO USING HYPERSPECTRAL IMAGING WITH A DORSAL SKINFOLD WINDOW CHAMBER

MCKEE, TREVOR D., CHEN, JUAN, CORBIN, IAN, ZHENG, GANG, KHOKHA, RAMA

Journal:

Journal of Innovative Optical Health Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 458 KB

english, 2012

The Role of Tissue Inhibitors of Metalloproteinases in Tumorigenesis and Metastasis

Cruz-Munoz, William, Khokha, Rama

Journal:

Critical Reviews in Clinical Laboratory Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 903 KB

english, 2008

Inflammation and breast cancer. Metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer

Carlo V Hojilla, Geoffrey A Wood, Rama Khokha

Journal:

Breast Cancer Research

Année:

2008

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2008

Metalloproteinases and their natural inhibitors in inflammation and immunity

Khokha, Rama, Murthy, Aditya, Weiss, Ashley

Journal:

Nature Reviews Immunology

Année:

2013

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2013

Fully Interlocking: A Story of Teamwork among Breast Epithelial Cells

Alexander, Caroline M., Joshi, Purna A., Khokha, Rama

Journal:

Developmental Cell

Année:

2014

Langue:

english

Fichier:

PDF, 288 KB

english, 2014

Independence of Metastatic Ability and Extravasation: Metastatic ras-Transformed and Control Fibroblasts Extravasate Equally Well

Sahadia Koop, Eric E. Schmidt, Ian C. MacDonald, Vincent L. Morris, Rama Khokha, Marsha Grattan, James Leone, Ann F. Chambers and Alan C. Groom

Journal:

Proceedings of the National Academy of Sciences

Année:

1996

Langue:

english

Fichier:

PDF, 1.41 MB

english, 1996

Insulin-Like Growth Factor II Signaling in Neoplastic Proliferation Is Blocked by Transgenic Expression of the Metalloproteinase Inhibitor TIMP-1

David C. Martin, John L. Fowlkes, Bojana Babic and Rama Khokha

Journal:

The Journal of Cell Biology

Année:

1999

Langue:

english

Fichier:

PDF, 1.66 MB

english, 1999

Binding to EGF Receptor of a Laminin-5 EGF-like Fragment Liberated during MMP-Dependent Mammary Gland Involution

Susann Schenk, Edith Hintermann, Martin Bilban, Naohiko Koshikawa, Carlo Hojilla, Rama Khokha and Vito Quaranta

Journal:

The Journal of Cell Biology

Année:

2003

Langue:

english

Fichier:

PDF, 3.43 MB

english, 2003

Localized interleukin-12 delivery for immunotherapy of solid tumours

Wei, Louis Z., Xu, Yixin, E. Nelles, Megan, Furlonger, Caren, Wang, James C.M., Di Grappa, Marco A., Khokha, Rama, Medin, Jeffrey A., Paige, Christopher J.

Journal:

Journal of Cellular and Molecular Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 596 KB

english, 2013

Intravitreal Injection of TIMP3 or the EGFR Inhibitor Erlotinib Offers Protection from Oxygen-Induced Retinopathy in Mice

Hewing, Nina Jasmin, Weskamp, Gisela, Vermaat, Joost, Farage, Eric, Glomski, Krzysztof, Swendeman, Steven, Chan, Robison Vernon Paul, Chiang, Michael F., Khokha, Rama, Anand-Apte, Bela, Blobel, Carl P

Journal:

Investigative Ophthalmology & Visual Science

Année:

2013

Langue:

english

Fichier:

PDF, 505 KB

english, 2013

Increased Neovascularization in Mice Lacking Tissue Inhibitor of Metalloproteinases-3

Ebrahem, Quteba, Qi, Jian Hua, Sugimoto, Masahiko, Ali, Mariya, Sears, Jonathan E., Cutler, Alecia, Khokha, Rama, Vasanji, Amit, Anand-Apte, Bela

Journal:

Investigative Ophthalmology & Visual Science

Année:

2011

Langue:

english

Fichier:

PDF, 1.76 MB

english, 2011

Progesterone Exposure and Breast Cancer Risk

Joshi, Purna A., Goodwin, Pamela J., Khokha, Rama

Journal:

JAMA Oncology

Année:

2015

Langue:

english

Fichier:

PDF, 306 KB

english, 2015

Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice

Jackson, Hartland W., Waterhouse, Paul, Sinha, Ankit, Kislinger, Thomas, Berman, Hal K., Khokha, Rama

Journal:

Nature Cell Biology

Année:

2015

Langue:

english

Fichier:

PDF, 4.93 MB

english, 2015

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1

Joshi, Purna A., Waterhouse, Paul D., Kannan, Nagarajan, Narala, Swami, Fang, Hui, Di Grappa, Marco A., Jackson, Hartland W., Penninger, Josef M., Eaves, Connie, Khokha, Rama

Journal:

Stem Cell Reports

Année:

2015

Langue:

english

Fichier:

PDF, 2.89 MB

english, 2015